Our latest publication in @NatureComms “Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops” advances our understanding of epigenetic gene regulation. Using a CRISPR screen, we found that PDS5A is a key player linking Polycomb-mediated silencing and 3D genome organization. Deletion of PDS5A disrupts cohesin activity, leading to unique genome architecture and the Read More…
Author: stanbell
Review how to define Heterochromatin
Heterochromatin is a key characteristic of eukaryotic genomes. Since its cytological description nearly 100 years ago, our understanding of heterochromatin features and functions, including transcription repression and genome stability, have continuously evolved. In this Viewpoint article, experts provide their current opinions on heterochromatin definition, types and functional mechanisms. Bell, O., Burton, A., Dean, C. et al. Heterochromatin definition Read More…
Our ZFP462 paper gets highlighted in Spectrum, the leading source of news and expert opinion on autism research.
New Pre-print on Biorxiv.
New preprint describes how defects in cohesin regulation reveal the repressive function of Polycomb long-range contacts. doi: https://doi.org/10.1101/2021.12.15.472841
Pre-print in Biorxiv
ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes Ramesh Yelagandula, Karin Stecher, Maria Novatchkova, Luca Michetti, Georg Michlits, Jingkui Wang, Pablo Hofbauer, Carina Pribitzer, Gintautas Vainorius, Luke Isbel, Sasha Mendjan, Dirk Schübeler, Ulrich Elling, Julius Brennecke, Oliver Bell Abstract: ZNF462 haploinsufficiency is linked to Weiss-Kruszka Syndrome, a genetic disorder characterized Read More…
Pre-print published in Biorxiv
REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR Junghyun L. Suh, Daniel Bsteh, Yibo Si, Bryce Hart, Tyler M. Weaver, Carina Pribitzer, Roy Lau, Shivani Soni, Heather Ogana, Justin M. Rectenwald, Jacqueline L. Norris, Stephanie H. Cholensky, Cari Sagum, Jessica D. Umana, Dongxu Li, Brian Hardy, Mark T. Bedford, Shannon M. Mumenthaler, Heinz-Josef Lenz, Yong-mi Kim, Gang Greg Wang, Ken H. Pearce, Lindsey I. James, Dmitri B. Kireev, Catherine A. Musselman, Stephen V. Frye, Oliver Bell ABSTRACT: Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their Read More…
