Weiss-Kruszka syndrome is a rare neurodevelopmental disorder characterized by craniofacial anomalies, developmental delay, and autistic features. Researchers at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences and the Keck School of Medicine of the University of Southern California (USC) in Los Angeles uncovered the molecular mechanism underlying Weiss-Kruszka syndrome: The causative Read More…
Category: News
New Pre-print on Biorxiv.
New preprint describes how defects in cohesin regulation reveal the repressive function of Polycomb long-range contacts. doi: https://doi.org/10.1101/2021.12.15.472841
Drug-like molecule points to novel strategies for cancer therapy
A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes. In a new study in Cell Chemical Biology, a team of scientists led by Oliver Bell from USC and Stephen V. Frye from Read More…
Pre-print in Biorxiv
ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes Ramesh Yelagandula, Karin Stecher, Maria Novatchkova, Luca Michetti, Georg Michlits, Jingkui Wang, Pablo Hofbauer, Carina Pribitzer, Gintautas Vainorius, Luke Isbel, Sasha Mendjan, Dirk Schübeler, Ulrich Elling, Julius Brennecke, Oliver Bell Abstract: ZNF462 haploinsufficiency is linked to Weiss-Kruszka Syndrome, a genetic disorder characterized Read More…
Pre-print published in Biorxiv
REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR Junghyun L. Suh, Daniel Bsteh, Yibo Si, Bryce Hart, Tyler M. Weaver, Carina Pribitzer, Roy Lau, Shivani Soni, Heather Ogana, Justin M. Rectenwald, Jacqueline L. Norris, Stephanie H. Cholensky, Cari Sagum, Jessica D. Umana, Dongxu Li, Brian Hardy, Mark T. Bedford, Shannon M. Mumenthaler, Heinz-Josef Lenz, Yong-mi Kim, Gang Greg Wang, Ken H. Pearce, Lindsey I. James, Dmitri B. Kireev, Catherine A. Musselman, Stephen V. Frye, Oliver Bell ABSTRACT: Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their Read More…
Paper Published in Science Advances
Design redundancy is not only an invention of engineers for building machines, but also a principle of nature for designing organisms. This principle is at play in the regulation of the genes responsible for directing stem cells to multiply themselves in the developing mouse embryo, as described in a new study in Science Advances. In Read More…
