2023

Bsteh D, Moussa HF, Michlits G, Yelagandula R, Wang J, Elling U, Bell O. Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops. Nat Commun. 2023 Dec 9;14(1):8160. doi: 10.1038/s41467-023-43869-w.

O Bell, A Burton, C Dean, SM Gasser, ME Torres-Padilla. Heterochromatin definition and function. Nature Reviews Molecular Cell Biology, 1-4 2023. doi: 10.1038/s41580-023-00599-7

Yelagandula R*, Stecher K*, Novatchkova M, Michetti L, Michlits G, Wang J, Hofbauer P, Pribitzer C, Vainorius G, Isbel L, Mendjan S, Schübeler D, Elling U, Brennecke J, Bell O. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers. Nat Cell Biol. 2023 Jan 5. doi: 10.1038/s41556-022-01051-2.

2021

Daniel Bsteh, Hagar F. Moussa, Georg Michlits, Ramesh Yelagandula, Jingkui Wang, Ulrich Elling, Oliver Bell. Loss of Cohesin regulator PDS5A reveals repressive role of Polycomb loops. BioRxiv pre-print 12.2021. doi: https://doi.org/10.1101/2021.12.15.472841

Suh JL, Bsteh D, Si Y, Hart B, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C,  Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV and Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2021 Oct 28; doi: 10.1016/j.chembiol.2021.10.003

Yelagandula R*, Stecher K*, Novatchkova M, Michetti L, Michlits G, Wang J, Hofbauer P, Pribitzer C, Vainorius G, Isbel L, Mendjan S, Schübeler D, Elling U, Brennecke J, Bell O. ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes. BioRxiv pre-print 02.2021. doi: https://doi.org/10.1101/2021.06.28.449463. *shared first authors

Suh JL, Bsteh D, Si Y, Hart B, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C,  Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV and Bell O. REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR. BioRxiv pre-print 02.2021. doi: https://doi.org/10.1101/2021.02.23.432388

2020

Zepeda-Martinez JA, Pribitzer C, Wang J, Bsteh D, Golumbeanu S, Zhao Q, Burkard TR, Reichholf B, Rhie SK, Jude J, Moussa HF, Zuber J, Bell O. Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells. Sci Adv. 2020 Apr;6(14):eaax5692. doi: 10.1126/sciadv.aax5692. eCollection 2020 Apr. PubMed PMID: 32270030; PubMed Central PMCID: PMC7112768.

2019

Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17;26(10):1365-1379.e22. doi: 10.1016/j.chembiol.2019.07.013. Epub 2019 Aug 15. PubMed PMID: 31422906; PubMed Central PMCID: PMC6800648.

Kruszka P, Hu T, Hong S, Signer R, Cogné B, Isidor B, Mazzola SE, Giltay JC, van Gassen KLI, England EM, Pais L, Ockeloen CW, Sanchez-Lara PA, Kinning E, Adams DJ, Treat K, Torres-Martinez W, Bedeschi MF, Iascone M, Blaney S, Bell O, Tan TY, Delrue MA, Jurgens J, Barry BJ, Engle EC, Savage SK, Fleischer N, Martinez-Agosto JA, Boycott K, Zackai EH, Muenke M. Phenotype delineation of ZNF462 related syndrome. Am J Med Genet A. 2019 Oct;179(10):2075-2082. doi: 10.1002/ajmg.a.61306. Epub 2019 Jul 30. PubMed PMID: 31361404; PubMed Central PMCID: PMC6935050.

MacDonald IA, Butler KV, Herring LE, Clinkscales SE, Yelagandula R, Stecher K, Bell O, Graves LM, Jin J, Hathaway NA. Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations. SLAS Discov. 2019 Sep;24(8):802-816. doi: 10.1177/2472555219849838. Epub 2019 May 30. PubMed PMID: 31145866; PubMed Central PMCID: PMC6893849.

Moussa HF*, Bsteh D*, Yelagandula R, Pribitzer C, Stecher K, Bartalska K, Michetti L, Wang J, Zepeda-Martinez JA, Elling U, Stuckey JI, James LI, Frye SV, Bell O. Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Nat Commun. 2019 Apr 29;10(1):1931. doi: 10.1038/s41467-019-09628-6. PubMed PMID: 31036804; PubMed Central PMCID: PMC6488670. *shared first authors

Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR. Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. Mol Cell. 2019 Jan 3;73(1):61-72.e3. doi: 10.1016/j.molcel.2018.10.028. Epub 2018 Nov 21. PubMed PMID: 30472189; PubMed Central PMCID: PMC6510544.

Elling U, Wimmer RA, Leibbrandt A, Burkard T, Michlits G, Leopoldi A, Micheler T, Abdeen D, Zhuk S, Aspalter IM, Handl C, Liebergesell J, Hubmann M, Husa AM, Kinzer M, Schuller N, Wetzel E, van de Loo N, Martinez JAZ, Estoppey D, Riedl R, Yang F, Fu B, Dechat T, Ivics Z, Agu CA, Bell O, Blaas D, Gerhardt H, Hoepfner D, Stark A, Penninger JM. A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature. 2017 Oct 5;550(7674):114-118. doi: 10.1038/nature24027. Epub 2017 Sep 27. PubMed PMID: 28953874; PubMed Central PMCID: PMC6235111.

Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015 Dec 10;528(7581):218-24. doi: 10.1038/nature15749. PubMed PMID: 26659182; PubMed Central PMCID: PMC4866648.

Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR. Dynamics and memory of heterochromatin in living cells. Cell. 2012 Jun 22;149(7):1447-60. doi: 10.1016/j.cell.2012.03.052. Epub 2012 Jun 14. PubMed PMID: 22704655; PubMed Central PMCID: PMC3422694.

Oli’s graduate school papers

Bell O, Tiwari VK, Thomä NH, Schübeler D. Determinants and dynamics of genome accessibility. Nat Rev Genet. 2011 Jul 12;12(8):554-64. doi: 10.1038/nrg3017. Review. PubMed PMID: 21747402.

Bell O, Schwaiger M, Oakeley EJ, Lienert F, Beisel C, Stadler MB, Schübeler D. Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Nat Struct Mol Biol. 2010 Jul;17(7):894-900. doi: 10.1038/nsmb.1825. Epub 2010 Jun 20. PubMed PMID: 20562853.

Bell O, Schübeler D. Chromatin: sub out the replacement. Curr Biol. 2009 Jul 28;19(14):R545-7. doi: 10.1016/j.cub.2009.06.032. Review. PubMed PMID: 19640486.

Schwaiger M, Stadler MB, Bell O, Kohler H, Oakeley EJ, Schübeler D. Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome. Genes Dev. 2009 Mar 1;23(5):589-601. doi: 10.1101/gad.511809. PubMed PMID: 19270159; PubMed Central PMCID: PMC2658520.

Bell O, Conrad T, Kind J, Wirbelauer C, Akhtar A, Schübeler D. Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster. Mol Cell Biol. 2008 May;28(10):3401-9. doi: 10.1128/MCB.00006-08. Epub 2008 Mar 17. PubMed PMID: 18347056; PubMed Central PMCID: PMC2423169.

Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A, Garza D, Peters AH, Schübeler D. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J. 2007 Dec 12;26(24):4974-84. doi: 10.1038/sj.emboj.7601926. Epub 2007 Nov 15. PubMed PMID: 18007591; PubMed Central PMCID: PMC2140113.

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW. Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood. 2005 Oct 1;106(7):2580-9. doi: 10.1182/blood-2005-04-1365. Epub 2005 Jun 14. PubMed PMID: 15956281.