Our latest publication in @NatureComms “Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops” advances our understanding of epigenetic gene regulation. Using a CRISPR screen, we found that PDS5A is a key player linking Polycomb-mediated silencing and 3D genome organization. Deletion of PDS5A disrupts cohesin activity, leading to unique genome architecture and the Read More…

Heterochromatin is a key characteristic of eukaryotic genomes. Since its cytological description nearly 100 years ago, our understanding of heterochromatin features and functions, including transcription repression and genome stability, have continuously evolved. In this Viewpoint article, experts provide their current opinions on heterochromatin definition, types and functional mechanisms. Bell, O., Burton, A., Dean, C. et al. Heterochromatin definition Read More…

“Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7,” by Lamb et. al. was published in Cell Chemical Biology on August 15, 2019.

The lab’s paper “Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing,” (Moussa & Bsteh et al. 2019) has been featured in Nature Communications’ Editors’ Highlights, under Carolina Perdigoto’s Genomes and Epigenomes focus.

“Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing,” by Moussa & Bsteh et al., was published in Nature Communications on April 29, 2019.