Our latest publication in @NatureComms “Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops” advances our understanding of epigenetic gene regulation. Using a CRISPR screen, we found that PDS5A is a key player linking Polycomb-mediated silencing and 3D genome organization. Deletion of PDS5A disrupts cohesin activity, leading to unique genome architecture and the…Continue Reading Our new paper revealing the repressive role of 3D Polycomb loops is out!
Year: 2023
Review how to define Heterochromatin
Heterochromatin is a key characteristic of eukaryotic genomes. Since its cytological description nearly 100 years ago, our understanding of heterochromatin features and functions, including transcription repression and genome stability, have continuously evolved. In this Viewpoint article, experts provide their current opinions on heterochromatin definition, types and functional mechanisms. Bell, O., Burton, A., Dean, C. et al. Heterochromatin definition…Continue Reading Review how to define Heterochromatin
Weiss-Kruszka syndrome and the failure to establish neuronal identity
Weiss-Kruszka syndrome is a rare neurodevelopmental disorder characterized by craniofacial anomalies, developmental delay, and autistic features. Researchers at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences and the Keck School of Medicine of the University of Southern California (USC) in Los Angeles uncovered the molecular mechanism underlying Weiss-Kruszka syndrome: The causative…Continue Reading Weiss-Kruszka syndrome and the failure to establish neuronal identity