Our latest publication in @NatureComms “Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops” advances our understanding of epigenetic gene regulation. Using a CRISPR screen, we found that PDS5A is a key player linking Polycomb-mediated silencing and 3D genome organization. Deletion of PDS5A disrupts cohesin activity, leading to unique genome architecture and the…Continue Reading Our new paper revealing the repressive role of 3D Polycomb loops is out!
