New preprint describes how defects in cohesin regulation reveal the repressive function of Polycomb long-range contacts. doi: https://doi.org/10.1101/2021.12.15.472841…Continue Reading New Pre-print on Biorxiv.
Year: 2021
Drug-like molecule points to novel strategies for cancer therapy
A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes. In a new study in Cell Chemical Biology, a team of scientists led by Oliver Bell from USC and Stephen V. Frye from…Continue Reading Drug-like molecule points to novel strategies for cancer therapy
Pre-print in Biorxiv
ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes Ramesh Yelagandula, Karin Stecher, Maria Novatchkova, Luca Michetti, Georg Michlits, Jingkui Wang, Pablo Hofbauer, Carina Pribitzer, Gintautas Vainorius, Luke Isbel, Sasha Mendjan, Dirk Schübeler, Ulrich Elling, Julius Brennecke, Oliver Bell Abstract: ZNF462 haploinsufficiency is linked to Weiss-Kruszka Syndrome, a genetic disorder characterized…Continue Reading Pre-print in Biorxiv
Pre-print published in Biorxiv
REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR Junghyun L. Suh, Daniel Bsteh, Yibo Si, Bryce Hart, Tyler M. Weaver, Carina Pribitzer, Roy Lau, Shivani Soni, Heather Ogana, Justin M. Rectenwald, Jacqueline L. Norris, Stephanie H. Cholensky, Cari Sagum, Jessica D. Umana, Dongxu Li, Brian Hardy, Mark T. Bedford, Shannon M. Mumenthaler, Heinz-Josef Lenz, Yong-mi Kim, Gang Greg Wang, Ken H. Pearce, Lindsey I. James, Dmitri B. Kireev, Catherine A. Musselman, Stephen V. Frye, Oliver Bell ABSTRACT: Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their…Continue Reading Pre-print published in Biorxiv